Jeff Stanton won the 1992 250cc USGP at Unadilla, taking the overall victory after winning the final two motos. The FIM changed the event format to three 30-minute motos due to grueling heat, high humidity, and rain conditions.

In Moto one Massimiliano Guzerada (Suzuki) grabbed the holeshot before crashing. Belgium's Peter Iven (Kawasaki) took over the lead, while 250cc newcomer Marnicq Bervoets (Yamaha) and charging American riders like Jeff Stanton (recovering from a 10th-place start) worked their way through the field.

World championship points leader Donnie Schmidt suffered a high-speed practice crash and was barred from joining Moto 1 after his gate spot was filled.After overcoming poor starts and a fall in the first moto, Stanton dominated by passing riders on the outside, holeshotted the third moto, and won motos two and three to claim the overall win.